Figure 48-1: Diagram of tail protein genome encoding regions for the coliphages K1, K5, K1-5 and the Salmonella phage SP6. All of these phages share a similar promoter region and an intergenic region with a putative transcription terminator. This 'modular' genomic construct suggests that a horizontal gene transfer mechanism for host range variation in nature that can be adapted for phage to be used as therapeutic antibacterial agents. In addition, these phages display additional qualities necessary for phages that will be used in antibacterial therapy; they produce progeny phage with a large burst size, and also show little if any loss of titer on storage. (for better image quality, click here for tif image, which may be quite large; may also require screen refreshing plus special software to view; or view larger tif in separate window)

Figure 48-1, Figure 48-2, Figure 48-3, Figure 48-4

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